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Rehab News: Research finds how alcohol reacts with genes in the brain

New research has shed light on how alcohol triggers the activation of a variety of genes that can influence the health and activity of brain cells.

New research from Weill Cornell Medical College in New York City may also help in the understanding of alcohol-linked disorders such as the brain damage associated with chronic alcoholism, and the abnormal brain development seen in the foetal alcohol syndrome (FAS).

A team led by Dr Neil L Harrison, professor of pharmacology and pharmacology in anesthesiology at Weill Cornell, studied cell cultures and in mouse neurons in vivo and found that alcohol stimulates "a ubiquitous, stress-linked biochemical cascade—called the heat shock pathway—to send a molecule called heat shock factor 1 (HSF1) into the neuron's nucleus".

"The big question that remains is how does this activation occur? The current theory holds that, under conditions of stress, heat shock proteins break away from a key molecule, HSF1. HSF1 then makes its way to the cell nucleus, where it helps stimulate the transcription and activation of a variety of genes that enable the cell to survive stress. We think this may happen with alcohol exposure," Dr Harrison explained.

He stressed that is was not clear what possible affects this may have clinically but the research is a stepping stone to further insights that could yield results.

Article published on 11/12/2007 by DryOutNow.com